Thread by @TomasoAntonacci on Thread Reader App

Tomaso Antonacci

May 1 • 44 tweets • 27 min read

1) Thread on the links between the microbiota and sars-cov 2 infections. It aims in particular to prevent the propensity to maintain the mystery around the long covid. #longcovid #covidlong #afterJ20

https://twitter.com/TomasoAntonacci/status/1520759647086465024

2) The microbiota is impacted by the virus, the alteration by sars-cov 2 infection is a recognized fact and the virus attacks the mucosa, this contributes to the mechanism of the inflammation @h_sokol pubmed.ncbi.nlm.nih.gov/32649864/

@h_sokol 3) The virus causes an inflammatory state which - in cascade - will rarefy the bacteria producing butyrate and anti-inflammatory metabolites.

@h_sokol 4) The microbiota also contributes to the prognosis / evolution of the disease:
inserm.fr/actualite/covi…

@h_sokol 5 ) The mechanism also applies to children with a share of PIMS linked to the presence of zonulin, a sign of intestinal permeability highlighted by Dr. Alessio Fasano:
jci.org/articles/view/…

@h_sokol 6) This intestinal permeability explains the dissemination of the virus in the organism and the multi-systemic nature of the symptoms which baffles so many physicians, heirs of the butcher Descartes. biorxiv.org/content/10.110…

@h_sokol 7) pre-print state but relatively sound in terms of reasoning:
biorxiv.org/content/10.110…

8) The underlying mechanisms are well described with the immunomodulatory role of the microbiota as described in this Indian publication:
link.springer.com/chapter/10.100…

9) Inflammation and severity of sars-cov is closely correlated to the state of the microbiota,
news-medical.net/news/20211101/… -19.aspx?fbclid=IwAR0ene82If5PhLOebTitRhu7IqPTBFmFykh_ZmFfI0dDIX vOeKAqR2jSgDQ

10) The state of the microbiota is also a predictor of the occurrence of #covidlong in this Anglo-German publication:
frontiersin.org/articles/10.33…

11) An American study from @TheWistar institute supports the principle:
medrxiv.org/content/10.110…

@TheWistar 12) This publication from Hong Kong demonstrates that the virus will alter the microbiota by creating a context opportunistic for latent co-infections:
gut.bmj.com/content/70/2/2…

13) Another international study (India, Australia and Saudi Arabia) confirms the relevance of the approach: https:/ /www.sciencedirect.com/science/article/pii/S000927972200103X?via%3Dihub&fbclid=IwAR2lUFKDA8mi8j0ZrYB9tVKpHmKXMdRyAfTNoGrFn1ZVxvG1JCsx9Z4K6Y8

14) Even in Tokyo, the topic attracts attention: journals.plos.org/?id310article/…

15) A metagenomic analysis campaign could have made it possible to identify risk profiles. It's not too late for the next waves … and that would be of interest for the prevention of a large number of diseases.

16) The symbiosis is disturbed with a context that has become opportunistic for fungal infections frontiersin.org/articles/10.33…

17) The issue is of interest from the acute phase, in India butyrate is considered because fungal infections cause damage:
ncbi.nlm.nih.gov/pmc/articles/P…

18) In France, a similar reflection is carried out by @manonjardou but it remains unfortunately, as too often in the field of fundamental research.
pubmed.ncbi.nlm.nih.gov/34385045/

@manonjardou 19) The intestine-lungs axis is correlated with the issue of microbiota and microbial translocation, the subject is also being studied in Brazil:
frontiersin.org/articles/10.33…

@manonjardou 20) The issue is also underlined in this American-Chinese publication, the presence of sars-cov in the intestine increases the severity of pulmonary involvement:
frontiersin.org/articles/10.33…

@manonjardou 21) They do, however, highlight the prevention this is for potential organ damage (and long covid ?). Prevention of long covid by taking oral probiotics at the time of infection (Universities of Bologna and Rome): frontiersin.org/articles/10.33…

@manonjardou 22 ) An American study converges with the results of the Italian study, taking probiotics reduces symptoms:
medrxiv.org/content/10.110…

@manonjardou 23) In Hong Kong there is interest too… the data converge! onlinelibrary.wiley.com/doi/10.1111/jg…

@manonjardou 24) Throat sprays with lactobacilli are also of interest:
https://www.news-medical. net/news/20220322/Study-evaluates-the-effectiveness-of-lactobacilli-throat-sprays-against-COVID-19.aspx?fbclid=

@manonjardou 25) Metabolites produced by bacteria play an important role in fighting infection:
medicalnewstoday.com/articles/some-…

@manonjardou 26 ) In Mexico too, there is interest in probiotics for the treatment of acute covid to speed up recovery:
tandfonline.com/doi/full/10.10…

@manonjardou 27) Poland,transplant faeces allows rapid resolution of acute covid… gut.bmj.com/content/71/1/2…

28) A good microbiota is obviously the first barrier against sars-cov, infections repeated do damage to this barrier. This is both a therapeutic angle and also a preventive one.

29) Here a strain of bacillus subtilis considered potentially useful from a therapeutic angle: pubmed.ncbi.nlm.nih.gov/35222320/

30) Should we be satisfied with the observation and regret it or rather make it a context of opportunity in terms of therapeutics? The mystery has a good back ... the Chinese are not mistaken.
nature.com/articles/s4139…

31) Faecal transplantation had already been proven for chronic fatigue syndrome too: sciencedirect.com/science/articl…

32) The care to be taken in the selection of donors is however not to be neglected, it is a technique that brings hope on the condition of being rigorous.

33) Once again, the Chinese have identified the problem of dysbiosis while in France it is the psychosomatic smoking theory that takes center stage:
gut.bmj.com/content/71/3/5…

34) Nutrition can play an obvious role even if it alone is not enough! In any case, it has more interest than cognitive-behavioral therapy.
nature.com/articles/s4143…

35) It is known that the blood-brain barrier can be impacted by an altered microbiota, which can favor the presence of pathogens the brain:
microbiomejournal.biomedcentral.com/articles/10.11…

36) should we emphasize that this is an open door to the development of neurological diseases -degenerative with @rudytanzi ? nature.com/articles/d4158….

@RudyTanzi 37) We are looking for markers of long covid but dysbiosis is not difficult to identify, the price of device for metagenomic sequencing starts at 1,000 euros.

@RudyTanzi 38) The overabundance of converging data raises questions. This seems all the more difficult to understand since - simultaneously - "specialists" are spending energy to demonstrate a psychosomatic pseudo-character of the long covid.

39) The absence of clinical trials in relation to the state of scientific knowledge in fundamental research also feeds the question. It can be seen that most of its data is produced by public research.

40) This is probably a symptom of the dysfunction of the health care system, with clinical research largely underfunded, which induces a form of private monopoly on the creation of new treatments.

41) it goes without saying that the persistence of the virus is closely correlated with the "dysimmunity" (to use the words of Prof. Salmon) caused by the alteration of the microbiota.

https://twitter.com/TomasoAntonacci/status/1461417626631118849

42) This produces wandering sick people, chronic diseases and much more expensive treatments than it could have been with major support from public research actors. The result for society = an expensive, inhumane and inefficient health care system.